Contiene : Tabla de contenido, índice, tablas y gráficas a blanco y negro, referencias bibliográficas al final de cada articulo

Articulo de la páginas 1205 - 1220

Incluye referencias bibliográficas (1218 - 1220)

Preface: Neonatal and Pediatric Clinical Pharmacology. Erratum. Pediatric Pharmacokinetics: Human Development and Drug Disposition.ediatric Pharmacogenomics: A Systematic Assessment of Ontogeny and Genetic Variation to Guide the Design of Statin Studies in Children. Metabolomics in the Developing Human Being. Emerging Biomarkers of Intrauterine Neonatal and Pediatric Exposures to Xenobiotics. New Ways to Detect Adverse Drug Reactions in Pediatrics. Pharmacotherapy of Pediatric HIV Infection. How to Optimize the Evaluation and Use of Antibiotics in Neonates. Pharmacotherapy for Pulmonary Hypertension. Pharmacologic Management of the Opioid Neonatal Abstinence Syndrome. Update on Pain Assessment in Sick Neonates and Infants. The Impact of Extracorporeal Life Support and Hypothermia on Drug Disposition in Critically Ill Infants and Children. Ethical Issues in Neonatal and Pediatric Clinical Trials.

Children have been identified as uniquely vulnerable clinical research subjects since the early 1970s. This article reviews the historical underpinnings of this designation, the current regulatory framework for pediatric and neonatal research, and common problems in pediatric research oversight. It also presents 3 areas of pediatric and neonatal research (genomic screening, healthy children donating stem cells, and therapeutic hypothermia for neonates with hypoxic-ischemic encephalopathy) that highlight contemporary challenges in pediatric research ethics, including balancing risk and benefit, informed consent and assent, and clinical equipoise

Ingles