With references

Part I. Overview of Genotoxicity testing and transgenic animal mutagenicity systems 2. Overview of genotoxicity testing 3. Construction/production of transgenic animals using as examples the Laci and Lacz mutation models 4. The transgenic mutagenicity assay - methodology using as examples Laci and Lacz mutation models 5. Further transgenic mutagenicity assays 6. Parameters and criteria for valid experimental desing Part II. Comparison of the Laci model and the Lacz model with conventional test systems 7. Introduction to part II 8. Comparison of the muta Mouse and Big Blue Assays 9. Transgenic Assays - Comparison with other assays 10. Transgenic Assays and Carcinogenicity Testing Part III. Applications of transgenic animal mutagenicity studies 11. Mutation frequencies and sequencing data and applications of this information in mechanistic studies Part IV: Evaluation, conclusions and recommendations 12. Evaluation of the transgenic animal mutagenicity assays based on this review of the current literature