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The family has long been considered a powerful influence on youth's high-risk behaviors. However, little is known about preventive family influences for gay and bisexual youth, a group at high risk for HIV infection. For this study, qualitative interviews from a sample of 38 gay and bisexual youth and their parents/guardians underwent a thematic analysis. Youth described parent-child closeness, parental warnings, and urgings to use condoms as influences. Youth denying family influence came from families in which parent-child relationships were disrupted or HIV-related discussion was lacking. Most families reported discomfort discussing HIV risk. These findings, along with a case example, suggest how family therapists can enhance parental influence by helping these families strengthen their relationships and discuss this important topic.